Ecumenical movements bridge the historic and ongoing disagreements within Christianity to fulfil Jesus’ desire that the church should be one. The early Christians struggled with questions of Christology, Trinity, and ecclesiological issues, among others, which were often resolved at ecumenical councils and synods. Today, churches still come together, not necessarily to resolve controversies but with socio-political interests. This paper assesses the trajectory of ecumenism, from its earliest roots to modern expressions, with an interest in Africa and Ghana. Through qualitative investigation of historical records, theological perspectives, and case studies of ecumenism in Africa and Ghana, the study exposes prominent achievements in dialogue, social justice, and reconciliation among different church denominations. Nevertheless, ecumenism in Africa faces doctrinal, hierarchical, and identity challenges. The study accentuates the relevance of ecumenism and calls for innovative approaches stimulated by the early Church’s unifying ethos to address 21st-century challenges. By building collaboration as unity in diversity, ecumenism can be a transformative tool for peacebuilding and social cohesion in a religiously diverse world, even within the same religion.